Method development
From molecule to method plan - before you touch the bench.
Enter a compound and matrix. ARISENTO gathers the compound data, finds published methods and drafts a method with every source listed - next to the methods your lab already approved.
What goes into a draft method
Compound data
Molecular weight, logP, pKa and structure from PubChem and ChEMBL.
Published methods
Europe PMC and OpenAlex, ranked by relevance to compound and matrix.
Mass & MRM
Precursor and product ions, isotope pattern - calculated by code.
Feasibility
Required LLOQ against expected Cmax, matrix and technique.
When the method misbehaves
The troubleshooting assistant works through the problem with your scientist - from your lab's approved methods and earlier fixes, with sources.
Backpressure
Pressure spikes and drifts - column, frit, mobile phase or system.
Retention time
Shifting or drifting retention - pH, temperature, column ageing, equilibration.
Peak shape
Split, tailing or broad peaks - injection solvent, column, extraction.
IS & matrix
IS response variation, ion suppression and carryover - what to check first.
When senior scientists move on, their knowledge stays
- Earlier analyses and approved methods shown before you start
- Trials, troubleshooting and conversations kept as read-only records
- Author signs, Manager approves with e-signature
- Only approved work enters the library and knowledge base - searchable in seconds
See method development for your compound
A 45-minute walkthrough of method development, AI Data Review and the compliance controls - with your own run files.